Pharmacological Effects of .SIGMA.-Receptor Ligands. Sigma (.SIGMA.) receptor and neurosteroids.
نویسندگان
چکیده
منابع مشابه
Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability.
The morphological effects of several neuroleptics as well as other novel and prototypic sigma ligands were examined by addition to cultures of C6 glioma cells. Sigma ligands caused loss of processes, assumption of spherical shape, and cessation of cell division. The time course and magnitude of this effect were dependent on the concentration of sigma ligand. Continued exposure to sigma compound...
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New racemic and chiral methyl 2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate derivatives were synthesized in order to obtain sigma ligands with increased affinity and selectivity compared to (+)-MPCB and haloperidol. The cis-(±)-7 racemic mixture showed a better binding affinity and selectivity than the (±)-8 trans isomers. Between the two cis enantiomers...
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It has been shown previously that sigma receptor agonists reveal potential antidepressant activity in experimental models. Moreover, some data indicate sigma receptor contribution to stress-induced responses (e.g., conditioned fear stress in mice), though the mechanism by which sigma ligands can exert their effects, remains unclear. Recent studies have indicated that antidepressant drugs (ADs) ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1999
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.114.51